pyrazoles-derivatives

Formula: C5H6N2O2In 2019 ,《Annular tautomerism of 3(5)-disubstituted-1H-pyrazoles with ester and amide groups》 appeared in Molecules. The author of the article were Kusakiewicz-Dawid, Anna; Porada, Monika; Dziuk, Blazej; Siodlak, Dawid. The article conveys some information:

A series of disubstituted 1H-pyrazoles with Me (1), amino (2), and nitro (3) groups, as well as ester (a) or amide (b) groups in positions 3 and 5 was synthesized, and annular tautomerism was investigated using X-ray, theor. calculations, NMR, and FT-IR methods. The X-ray experiment in the crystal state showed for the compounds with Me (1a, 1b) and amino (2b) groups the tautomer with ester or amide groups at position 3 (tautomer 3), but for those with a nitro group (3b, 4), tautomer 5. Similar results were obtained in solution by NMR NOE experiments in CDCl3, DMSO-d6, and CD3OD solvents. However, tautomer equilibrium was observed for 2b in DMSO. The FT-IR spectra in chloroform and acetonitrile showed equilibrium, which can be ascribed to conformational changes of the cis/trans arrangement of the ester/amide group and pyrazole ring. Theor. anal. using the M06-2X/6-311++G(d,p) method (in vacuo, chloroform, acetonitrile, and water) and measurement of aromaticity (NICS) showed dependence on internal hydrogen bonds, the influence of the environment, and the effect of the substituent. These factors, pyrazole aromaticity and intra- and inter-mol. interactions, seem to have a considerable influence on the choice of tautomer. The results came from multiple reactions, including the reaction of Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4Formula: C5H6N2O2)

Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Formula: C5H6N2O2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Electric Literature of C4H3F3N2In 2016 ,《η1:η2-P-pyrazolylphosphaalkene complexes of ruthenium(0)》 appeared in Inorganics. The author of the article were Greenacre, Victoria K.; Crossley, Ian R.. The article conveys some information:

An extended range of novel ruthenium phosphaalkene complexes of the type [Ru{η1-N:η2-P,C-P(pz’):CH(SiMe2R)}(CO)(PPh3)2] (R = Tol, C6H4CF3-p; pz’ = pzMe2, pzCF3, pzMe,CF3; R = Me, C6H4CF3-p; pz’ = pzPh) have been prepared from the resp. ruthenaphosphaalkenyls [Ru{P:CH(SiMe2R)}Cl(CO)(PPh3)2] upon treatment with Lipz’. Where R = C6H4CF3-p and pz’ = pzMe2 the complex is characterized by single crystal x-ray diffraction, only the second example of such species being structurally characterized. This indicates enhanced pyramidalization of the alkenic carbon center when compared with precedent data (R = Me, pz’ = pz) implying an enhanced Ru→π*PC contribution, which can be correlated with the greater donor power of pzMe2. This is similarly reflected in spectroscopic data that reveal significant influence of the pyrazolyl substituents upon the phosphaalkene, stronger donors imparting significantly enhanced shielding to phosphorus; in contrast, a much lesser influence if noted for the silyl substituents. The results came from multiple reactions, including the reaction of 3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4Electric Literature of C4H3F3N2)

3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Electric Literature of C4H3F3N2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Related Products of 15366-34-4In 2001 ,《Synthesis of a terbium fluorescent chelate and its application to time-resolved fluoroimmunoassay》 was published in Analytical Chemistry. The article was written by Yuan, Jingli; Wang, Guilan; Majima, Keisuke; Matsumoto, Kazuko. The article contains the following contents:

A new nonadentate ligand, N, N, N1, N1-[2,6-bis(3′-aminomethyl-1′-pyrazolyl)-4-phenylpyridine]tetrakis(acetic acid) (BPTA) for a Tb3+ fluorescent complex was synthesized. The Tb3+ complex is strongly fluorescent, having a large fluorescence quantum yield of 1.00 and very long fluorescence lifetime of 2.681 ms in 0.05 M borate buffer of pH 9.1. Streptavidin (SA) was labeled with BPTA by using its succinimidyl monoester, and the BPTA-Tb3+-labeled SA was used in sandwich-type time-resolved fluoroimmunoassay (TR-FIA) of α-fetoprotein (AFP) and carcinoembryonic antigen (CEA) in human sera. The Tb3+-labeled SA was also used in competitive-type TR-FIA of bensulfuron-Me (BSM) in water. The detection limits of these assays are 42 pg/mL for AFP, 70 pg/mL for CEA, and 0.4 ng/mL for BSM. In addition, a new simultaneous measurement method for AFP and CEA in a human serum sample was developed by using 4,4′-bis(1”,1”,1”,2”,2”,3”,3” -heptafluoro-4”,6”-hexanedion-6”-yl)chlorosulfo-o-terphenyl (BHHCT)-Eu3+-labeled anti-AFP antibody, biotinylated anti-CEA antibody, and BPTA-Tb3+-labeled SA. The concentrations of AFP and CEA in 39 human serum samples were determined, and the results were compared with those of the independently determined AFP and CEA by TR-FIA with a single-label method. A good correlation was obtained with the correlation coefficients of 0.991 for AFP and 0.994 for CEA. The results came from multiple reactions, including the reaction of Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4Related Products of 15366-34-4)

Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Related Products of 15366-34-4

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

《Combination of experimental and theoretical methods to explore the amino-functionalized pyrazolium ionic liquids: An efficient single-component catalyst for chemical fixation of CO2 under mild conditions》 was written by Zhang, Jingshun; Zhu, Xinrui; Fan, Baowan; Guo, Jia; Ning, Pan; Ren, Tiegang; Wang, Li; Zhang, Jinglai. Recommanded Product: 930-36-9 And the article was included in Molecular Catalysis on April 30 ,2019. The article conveys some information:

Four new amino-functionalized pyrazolium ionic liquids, I [R = Me, Et; n = 1, 2] were firstly synthesized in simple reaction steps with cheap raw materials. Ionic liquids I would catalyze the coupling reaction of carbon dioxide with propyleneoxide under optimal reaction conditions, 110 °C, 1.5 MPa carbon dioxide initial pressure as well as 1.0 mol% catalyst amount for 4.0 h, with propylene carbonate yield over 94%. The reaction temperature was decreased by 10-20 °C as compared with other single-component ionic liquids and at the same time, carbon dioxide initial pressure was not increased to keep 1.5 MPa. The recyclability and suitability of amino-functionalized pyrazolium ionic liquids were explored and catalytic mechanism was investigated by d. functional theory. Moreover, the influence of weak interactions on reaction was analyzed by atoms in mols. and non-covalent interactions. As compared with other reported ionic liquids, the reaction condition catalyzed by ionic liquid I [R = Et, n = 2] was more benign with comparable product yield. More importantly, there was good balance among various reaction conditions without sacrificing one to ensure others. In addition to this study using 1-Methylpyrazole, there are many other studies that have used 1-Methylpyrazole(cas: 930-36-9Recommanded Product: 930-36-9) was used in this study.

1-Methylpyrazole(cas: 930-36-9) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Recommanded Product: 930-36-9

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

《Pyrazole-3/5-carboxylic acids from 3/5-trifluoromethyl NH-pyrazoles》 was written by Ermolenko, Mikhail S.; Guillou, Sandrine; Janin, Yves L.. Safety of 3-(Trifluoromethyl)-1H-pyrazoleThis research focused ontrifluoromethylpyrazole pyrazole carboxylic acid preparation. The article conveys some information:

The transformations of substituted 3/5-trifluoromethylpyrazoles to the corresponding NH-pyrazole-3/5-carboxylic acids are reported. Moreover, from 4- or 5-iodinated-3/5-trifluoromethylpyrazoles building blocks and the use of Suzuki-Miyaura or Negishi reactions followed by the trifluoromethyl hydrolysis, we illustrate short and original accesses to many series of NH-pyrazole-3/5-carboxylic acids otherwise difficult to prepare After reading the article, we found that the author used 3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4Safety of 3-(Trifluoromethyl)-1H-pyrazole)

3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Safety of 3-(Trifluoromethyl)-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

The author of 《A new synthesis of azolooxazines》 were Lupo, B.; Tarrago, G.. And the article was published in Synthetic Communications in 1982. COA of Formula: C5H8N2O The author mentioned the following in the article:

Pyrazolooxazine derivative I was prepared from 3(5)-hydroxymethyl-5(3)-methylpyrazole (II) in two steps. II was heated with propargyl bromide in DMF to yield a mixture of III (R = CH2OH, R1 = Me) and III (R = Me, R1 = CH2OH) (IV). A mixture of IV, Bu4N+ Br-, and NaOH in C6H6 was stirred 4 h at 60° to give I. In the experiment, the researchers used many compounds, for example, (3-methyl-1H-pyrazol-5-yl)methanol(cas: 29004-73-7COA of Formula: C5H8N2O)

(3-methyl-1H-pyrazol-5-yl)methanol(cas: 29004-73-7) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. COA of Formula: C5H8N2O

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In 1959,Graner, R. Franquesa published 《Synthesis of 2-acetamido-5-nitrothiazole, an oral bactericide》.Galenica Acta published the findings.Application In Synthesis of Methyl 1H-pyrazole-3-carboxylate The information in the text is summarized as follows:

Tech. 2-aminothiazole-HCl was purified by neutralizing with NaOH at 50°, cooling with the addition of the solid amine to prevent supercooling, washing at pH 11-12, then with a saturated solution of NaCl, and then H2O. The solid was air-dried and distilled, b12 139-43°; 65% 2-aminothiazole (I) was recovered. Preparation of 2-acetamido-5-nitrothiazole (II) (CA 46, 10285h; 40, 40583) was accomplished by acetylation, then nitration of I (78.2% over-all yield), and by the reverse steps (62.8% over-all). Ac2O (1.3 mole), 1 mole I, and 0.1 mole H2SO4 was refluxed 10 min., poured on ice, and the solid recrystallized m. 209-10°, for a 92% yield of 2-acetamidothiazole (III). III (142 g.) was dissolved in 450 ml. concentrated H2SO4 at 10° with the addition of 46 ml. (d. 1.5) fuming HNO3 over 40 min.; allowing the temperature to reach 50° for 30 min., pouring on ice, filtering, and washing with water, EtOH, and recrystallizing from AcOH (50 ml./5 g.) gave 152 g. II, m. 265-6°. I (100 g.) was dissolved in 300 ml. concentrated H2SO4 at 10°, and 46 ml. (d. 1.5) fuming HNO3 was added dropwise with agitation at 12°. The temperature was kept 3 hrs. at 0°, then at 25° for 24 hrs. The mass was poured onto 5000 ml. icewater, and the filtrate neutralized with 600 g. Na2CO3 in 2000 ml. H2O. The product was water-washed, and recrystallized from EtOH (100 ml./5 g.) to give 100 g. 2-amino-5-nitrothiazole (IV), m. 202-3°. IV (7 g.), 50 ml. Ac2O, and 3 drops of concentrated H2SO4 were refluxed 7 min., and cooled to 0°. Recrystallization of the solid from AcOH gave 8.5 g. II, m. 265°. In the experiment, the researchers used Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4Application In Synthesis of Methyl 1H-pyrazole-3-carboxylate)

Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4) belongs to pyrazoles. The application of pyrazole derivatives in the development of anticancer agents has been thoroughly investigated and verified. Moreover, the medicinal features of a number of natural products incorporating pyrazole moiety such as pyrazofurin, pyrazofurin B, pyrazole-3(5)-carboxylic acid and 4-methylpyrazole-3(5)-carboxylic acid have been reported.Application In Synthesis of Methyl 1H-pyrazole-3-carboxylate

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In 2015,Liao, Jia-Ling; Chi, Yun; Sie, Zong-Ting; Ku, Chia-Hao; Chang, Chih-Hao; Fox, Mark A.; Low, Paul J.; Tseng, Meu-Rurng; Lee, Gene-Hsiang published 《Ir(III)-Based Phosphors with Bipyrazolate Ancillaries; Rational Design, Photophysics, and Applications in Organic Light-Emitting Diodes》.Inorganic Chemistry published the findings.Recommanded Product: 20154-03-4 The information in the text is summarized as follows:

Three charge-neutral Ir(III) complexes bearing both neutral chelating ligands 4,4′-di-t-butyl-2,2′-bipyridine (dtbbpy) and monoanionic cyclometalated ligands derived from 2-phenylpyridine (ppyH), together with either 2 monoanionic ligands (i.e., chloride and monodentate pyrazolate) or a single dianionic chelate derived from 5,5′-di(trifluoromethyl)-3,3′-bipyrazole (bipzH2) or 5,5′-(1-methylethylidene)-bis-(3-trifluoromethyl-1H-pyrazole) (mepzH2), was successfully synthesized. These complexes are derived from a common, structurally characterized, Ir(III) intermediate complex [Ir(dtbbpy)(ppy)Cl2] (1), from treatment of IrCl3·3H2O with equal amount of the diimine (NN̂) and precursor of the cyclometalated (C^N) ligands in a form of 1-pot reaction. Treatment of 1 with various functional pyrazoles afforded [Ir(dtbbpy)(ppy)(pz)Cl] (2), [Ir(dtbbpy)(ppy)(bipz)] (3), and [Ir(dtbbpy)(ppy)(mepz)] (4), which display intense room-temperature emission with λmax spanning 532-593 nm in both fluid and solid states. The Ir(III) complexes, 3 and 4, showcase rare examples of 3 distinctive chelates (i.e., neutral, anionic, and dianionic) assembled around the central Ir(III) cation. Hybrid d. functional theory (DFT; B3LYP) electronic structure calculations on 1-4 reveal the LUMO to be π*(bpy) in character for all complexes and HOMO offering d(Ir)-π(phenyl) character for 1, 2, and 4 and π(bipz) character for 3. The different HOMO composition of 3 and 4 is also predicted by calculations using pure DFT (BLYP) and wave function (MP2) methods. From time-dependent DFT calculations, the emissive processes are dominated by the Ph group-to-bipyridine, ligand(ppy)-to-ligand(bpy) charge transfer admixed with metal-to-ligand transition for all Ir(III) complexes. Organic light emitting diodes were successfully fabricated. A double emitting layer design was adopted in the device architecture using Ir(III) metal complexes 3 and 4, attaining peak external quantum efficiencies, luminance efficiencies, and power efficiencies of 18.1% (59.0 cd/A and 38.6 lm/W) and 16.6% (53.3 cd/A and 33.5 lm/W), resp. The experimental process involved the reaction of 3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4Recommanded Product: 20154-03-4)

3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Recommanded Product: 20154-03-4

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In 2016,Aitha, Anjaiah; Yennam, Satyanarayana; Behera, Manoranjan; Anireddy, Jaya Shree published 《Design and synthesis of diaziridinyl quinone thiadiazole hybrids via nitrile sulfide cycloaddition reaction as a key step》.Tetrahedron Letters published the findings.Quality Control of 3-(Trifluoromethyl)-1H-pyrazole The information in the text is summarized as follows:

A series of novel diaziridinyl quinone thiadiazole hybrids (I; R = N-heterocycle) were synthesized starting from 2-hydroxy-5-methoxybenzoic acid in a 7 step synthetic sequence. The key step in the scheme involves the nitrile sulfide cycloaddition reaction of oxathiazolone II with p-tosyl cyanide to obtain 1,2,4-thiadiazole derivative III. We have demonstrated that p-tosyl group of thiadiazole 5 can be displaced with various nitrogen heterocycles to generate unknown 3,5-disubstituted thiadiazole derivatives In the experiment, the researchers used 3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4Quality Control of 3-(Trifluoromethyl)-1H-pyrazole)

3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. The application of pyrazole derivatives in the development of anticancer agents has been thoroughly investigated and verified. Moreover, the medicinal features of a number of natural products incorporating pyrazole moiety such as pyrazofurin, pyrazofurin B, pyrazole-3(5)-carboxylic acid and 4-methylpyrazole-3(5)-carboxylic acid have been reported.Quality Control of 3-(Trifluoromethyl)-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In 2017,Al Mousawi, Assi; Kermagoret, Anthony; Versace, Davy-Louis; Toufaily, Joumana; Hamieh, Tayssir; Graff, Bernadette; Dumur, Frederic; Gigmes, Didier; Fouassier, Jean Pierre; Lalevee, Jacques published 《Copper photoredox catalysts for polymerization upon near UV or visible light: structure/reactivity/efficiency relationships and use in LED projector 3D printing resins》.Polymer Chemistry published the findings.Recommanded Product: 3-(Trifluoromethyl)-1H-pyrazole The information in the text is summarized as follows:

Copper complexes (CuCs) bearing pyridine-pyrazole ligands are synthesized and evaluated as new photocatalysts/photoinitiators in combination with an iodonium salt (Iod) for the free radical polymerization of (meth)acrylates and the cationic polymerization of epoxides upon visible light exposure using Light Emitting Diode (LED)@405nm. The structure/reactivity/efficiency relationships for the copper complexes are studied as well as the chem. mechanisms involved. The different substituents on the pyrazole moiety of the ligand allow to tune the oxidation potential and the visible light absorbance of the complexes and to optimize the performance of the polymerization photocatalysts. The use of a novel additive (CARET) in a three-component system (CuC/Iod/CARET) highly improves the performance. Finally, the high performances of the Cu(I) complexes for the development of new 3D printing resins using LED projector are demonstrated. Currently, LED projector printing is really advantageous in 3D printing i.e. this technol. projects the profile of an entire layer at one time.3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4Recommanded Product: 3-(Trifluoromethyl)-1H-pyrazole) was used in this study.

3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. The application of pyrazole derivatives in the development of anticancer agents has been thoroughly investigated and verified. Moreover, the medicinal features of a number of natural products incorporating pyrazole moiety such as pyrazofurin, pyrazofurin B, pyrazole-3(5)-carboxylic acid and 4-methylpyrazole-3(5)-carboxylic acid have been reported.Recommanded Product: 3-(Trifluoromethyl)-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics