Electric Literature of C4H3F3N2In 2016 ,《η1:η2-P-pyrazolylphosphaalkene complexes of ruthenium(0)》 appeared in Inorganics. The author of the article were Greenacre, Victoria K.; Crossley, Ian R.. The article conveys some information:
An extended range of novel ruthenium phosphaalkene complexes of the type [Ru{η1-N:η2-P,C-P(pz’):CH(SiMe2R)}(CO)(PPh3)2] (R = Tol, C6H4CF3-p; pz’ = pzMe2, pzCF3, pzMe,CF3; R = Me, C6H4CF3-p; pz’ = pzPh) have been prepared from the resp. ruthenaphosphaalkenyls [Ru{P:CH(SiMe2R)}Cl(CO)(PPh3)2] upon treatment with Lipz’. Where R = C6H4CF3-p and pz’ = pzMe2 the complex is characterized by single crystal x-ray diffraction, only the second example of such species being structurally characterized. This indicates enhanced pyramidalization of the alkenic carbon center when compared with precedent data (R = Me, pz’ = pz) implying an enhanced Ru→π*PC contribution, which can be correlated with the greater donor power of pzMe2. This is similarly reflected in spectroscopic data that reveal significant influence of the pyrazolyl substituents upon the phosphaalkene, stronger donors imparting significantly enhanced shielding to phosphorus; in contrast, a much lesser influence if noted for the silyl substituents. The results came from multiple reactions, including the reaction of 3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4Electric Literature of C4H3F3N2)
3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Electric Literature of C4H3F3N2
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics