《Pyrazole-3/5-carboxylic acids from 3/5-trifluoromethyl NH-pyrazoles》 was written by Ermolenko, Mikhail S.; Guillou, Sandrine; Janin, Yves L.. Safety of 3-(Trifluoromethyl)-1H-pyrazoleThis research focused ontrifluoromethylpyrazole pyrazole carboxylic acid preparation. The article conveys some information:
The transformations of substituted 3/5-trifluoromethylpyrazoles to the corresponding NH-pyrazole-3/5-carboxylic acids are reported. Moreover, from 4- or 5-iodinated-3/5-trifluoromethylpyrazoles building blocks and the use of Suzuki-Miyaura or Negishi reactions followed by the trifluoromethyl hydrolysis, we illustrate short and original accesses to many series of NH-pyrazole-3/5-carboxylic acids otherwise difficult to prepare After reading the article, we found that the author used 3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4Safety of 3-(Trifluoromethyl)-1H-pyrazole)
3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Safety of 3-(Trifluoromethyl)-1H-pyrazole
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics