In 1985,Juanes, Olga; De Mendoza, Javier; Rodriguez-Ubis, Juan Carlos published 《Synthesis of macrobicyclic ligands containing pyrazole subunits: the N,N’-bipyrazolyl cryptand》.Journal of the Chemical Society, Chemical Communications published the findings.Recommanded Product: 15366-34-4 The information in the text is summarized as follows:
The cryptands I and II were prepared in 19 and 56% yield, resp., by reaction of 3,3′-bis(bromomethyl)-1,1′-bipyrazole with anhydrous NH3 and 4,13-diaza-1,7,10,16-tetraoxacyclooctadecane, resp., in dry MeCN at 100°. The tripodal pyrazolyl ligands III (R = H, Me, CH2Ph) were prepared analogously in 35, 41, and 39% yield, resp., by reaction of the appropriate pyrazoles IV with anhydrous NH3. After reading the article, we found that the author used Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4Recommanded Product: 15366-34-4)
Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4) belongs to pyrazoles. The application of pyrazole derivatives in the development of anticancer agents has been thoroughly investigated and verified. Moreover, the medicinal features of a number of natural products incorporating pyrazole moiety such as pyrazofurin, pyrazofurin B, pyrazole-3(5)-carboxylic acid and 4-methylpyrazole-3(5)-carboxylic acid have been reported.Recommanded Product: 15366-34-4
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics