Wang, Yuzhuo; Wang, Lei; Chen, Mingjie; Tu, Youshao; Liu, Yu; Zhang, Junliang published an article about the compound: 6-Bromo-2,3-dihydrobenzo[b][1,4]dioxine( cas:52287-51-1,SMILESS:BrC1=CC=C2OCCOC2=C1 ).Application of 52287-51-1. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:52287-51-1) through the article.
An efficient palladium-catalyzed enantioselective carboamination reaction of N-Boc-O-homoallyl-hydroxylamines and N-Boc-pent-4-enylamines with aryl or alkenyl bromides was developed, delivering various substituted isoxazolidines I [R = H, Me; R1 = Ph, 3-thienyl, 2-naphthyl, etc.] and pyrrolidines II [R1 = 4-PhC6H4, 3,4-MeO2C6H3, 1-naphthyl, etc.; R2 = H, Me; R3 = Boc, Cbz] in good yields with up to 97% ee. The reaction featured mild conditions, general substrate scope and scalability. The obtained products could be transformed into chiral 1,3-aminoalc. derivatives without erosion of chirality. The newly identified Xu-Phos ligand bearing an ortho-OiPr group was responsible for the good yield and high enantioselectivity.
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Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics