Related Products of 3398-16-1, The chemical industry reduces the impact on the environment during synthesis 3398-16-1, name is 4-Bromo-3,5-dimethylpyrazole, I believe this compound will play a more active role in future production and life.
4-Bromo-3,5-dimethylpyrazole (3.5714 g, 20 mmol, 98%, 1.0 eq.) was added sequentially to a dry three-neck flask with a magnetic rotor.Phenylboronic acid (2.9552g, 24mmol, 99%, 1.2 equivalents),Palladium acetate (0.1123 g, 0.5 mmol, 0.025 equivalent),Ligand S-Phos (0.5027 g, 1.2 mmol, 98%, 0.06 equivalents),1,4-Dioxane (60 mL) and potassium carbonate (8.2920 g, 60 mmol, 3.0 eq.)Aqueous solution (20 mL). nitrogenAir bubbling for 15 minutes,The reaction vial was then placed in a 115 C oil bath.After stirring for 15 hours,The reaction was monitored by thin layer chromatography.Cool to room temperature,Extract with dichloromethane (20 mL x 3).Combine all organic phases,Dry over anhydrous sodium sulfate.Filtered, concentrated,The crude product was purified by flash chromatography on silica gel column chromatography (eluent: petroleum ether / ethyl acetate = 3/1 to 1/2) to give 3,5-dimethyl-4-phenylpyrazole, white The solid was 3.0773 g, and the yield was 89%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-3,5-dimethylpyrazole, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Zhejiang University of Technology; Ruisheng Optoelectric Science And Technology (Changzhou) Co., Ltd.; Li Guijie; Feng Qi; Dai Jianxin; Zhao Xiangdong; Chen Shaohai; She Yuanbin; (64 pag.)CN109608506; (2019); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics