Reference of 632365-54-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 632365-54-9 as follows.
Step d: To a solution of methyl 5-amino-1 H-pyrazole-3-carboxylate (75 mg; 0.53 mmol) in DMF (2 mL) was added the 2-bromo-2-cyclohexyl-1-(4-fluorophenyl)ethanone ( 170 mg; 0.58 mmol) followed by potassium carbonate (263 mg; 2.66 mmol) and the reaction mixture was stirred at 75C. After 2 hours water (25 mL) was added and the aqueous layer was extracted with EtOAc (3 x 30 mL). The combined organics were washed with brine (25 mL), dried (MgS04) and concentrated to leave a brown oil (89 mg). The residue was redissolved in EtOH ( 2 mL) and 2M sulphuric acid (0.5 mL) was added and the reaction mixture was stirred at 70 C. After 2 hours NaHC03 (25 ml) was added and the aqueous layer was extracted with EtOAc (3 x 30 mL). The combined organics were washed with brine (25 mL), dried (MgS04) and concentrated to leave a brown oil (75 mg). Purification by reverse phase LCMS: Acetonitrile/water (0.1 % formic acid) afforded methyl 3-cyclohexyl-2-(4-fluorophenyl)- 1 H-imidazo[1 ,2-b]pyrazole-6-carboxylate (i) (8.5 mg) as an amorphous white solid. ESI-MS m/z calculated for [M+H]+: 342.16; found: 342.09.
According to the analysis of related databases, 632365-54-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BIOTA SCIENTIFIC MANAGEMENT PTY LTD; FREY, Barbara; HUFTON, Richard; HARDING, Michael; DRAFFAN, Alistair George; WO2013/36994; (2013); A1;,
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