Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 578008-32-9, name is tert-Butyl 3-amino-5-methyl-1H-pyrazole-1-carboxylate, A new synthetic method of this compound is introduced below., Product Details of 578008-32-9
Nitrogen was bubbled through a mixture of (S) -2,6- dichloro-4- (3-fluororhoyrrolidin-1-yl) pyridine (600 mg, 2.6 mmol) , tert-butyl S-amino-S-methyl-lH-pyrazole-l-carboxylate(510 mg, 2.6 mmol), Pd2dba3 (119 mg) , xantphos (150 mg) , and sodium carbonate (382 mg, 3.6 mmol) in dioxane (10 mL) . The mixture was heated to 140 0C for 45 minutes and then to 170 0C for 15 minutes in the microwave. After filtration through Celite and a dioxane rinse, the solvents were removed under reduced pressure. The residue was purified by column chromatography (SiO2 (75 mL) , CH2C12/2.5-7% 2-propanol; TLC: CH2C12/5% 2-propanol, Rf=O.3) to yield 230 mg of the desired product as an off-white solid (HPLC: Rf=7.341 minutes) .
The synthetic route of 578008-32-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; WO2008/147626; (2008); A2;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics