Adding a certain compound to certain chemical reactions, such as: 400755-44-4, name is 1-Ethylpyrazole-3-carboxylic Acid, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 400755-44-4, Computed Properties of C6H8N2O2
To a solution of 1 -ethyl- 7/-/-pyrazole-3-carboxylic acid (1 1 1 mg, 0.793 mmol) and diisopropylethylamine (307 mg, 2.379 mmol) in tetrahydrofuran (4.0 ml_) at 20 C was added 1 -[b/s(dimethylamino)methylene]- 7/-/-1 ,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate (452 mg, 1 .19 mmol). The reaction mixture was stirred for 20 minutes before a solution of 5-(3-fluorobenzyl)pyridin-2-amine (160 mg, 0.793 mmol) in tetrahydrofuran (1 .0 ml_) was added. The solution mixture was stirred at 20 C for 16 h. The volatiles were removed under reduced pressure and the residue was added to a mixture of dichloromethane (50 ml_) and water (50 ml_). The combined organic layers were collected, dried over sodium sulfate, filtered and concentrated. The crude sample was dissolved in minimal A/,A/-dimethylformamide and purified via prep-HPLC (Boston C18 21 *250 mm 10 pm column; acetonitrile/0.01 % aqueous trifluoroacetic acid) to give 1 -ethyl-A/-(5-(3-fluorobenzyl)pyridin-2-yl)- 7/-/-pyrazole-3-carboxamide (43.0 mg, 0.132 mmol, 16.7%) as a white solid. 1 H NMR (400 MHz, Dimethylsulfoxide-c/6) d 9.51 (s, 1 H), 8.27 (d, J = 2.0 Hz, 1 H), 8.08 (d, J = 8.5 Hz, 1 H), 7.92 (d, J = 2.3 Hz, 1 H), 7.71 – 7.70 (dd, J = 8.5, 2.2 Hz, 1 H), 7.33 – 7.30 (dd, J = 14.3, 8.0 Hz, 1 H), 7.10 – 7.08 (t, J = 7.0 Hz, 2H), 7.02 – 7.01 (dd, J = 1 1 .9, 5.3 Hz, 1 H), 6.82 (d, J = 2.3 Hz, 1 H), 4.23 – 4.21 (q, J = 7.3 Hz, 2H), 3.95 (s, 2H), 1 .41 – 1 .40 (t, J = 7.3 Hz, 3H).; LCMS (ESI) m/z: 325.1 [M+H]+.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Ethylpyrazole-3-carboxylic Acid, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; YUMANITY THERAPEUTICS, INC.; LE BOURDONNEC, Bertrand; LUCAS, Matthew; OZBOYA, Kerem; PANDYA, Bhaumik; TARDIFF, Daniel; TIVITMAHAISOON, Parcharee; WRONA, Iwona; (475 pag.)WO2019/183587; (2019); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics