Related Products of 56984-32-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 56984-32-8 name is Ethyl 5-chloro-1-methyl-1H-pyrazole-4-carboxylate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: In a microwave reaction vessel was combined 15(300 mg, 1.59 mmol), phenol (300 mg, 3.19 mmol) and Cs2CO3(1.52 g, 4.66 mmol) in DMF. The vessel was sealed and the resulting mixture was heated at 120C by microwave for30 min. Then the reaction mixture was cooled to r.t., quenched with water and extracted with EtOAc three times. The organic layer was collected, washed with brine, dried over MgSO4 and filtered. After the solvent was removed, the crude was purified by flash column chromatography to yield 16a
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Ethyl 5-chloro-1-methyl-1H-pyrazole-4-carboxylate, and friends who are interested can also refer to it.
Reference:
Article; Chen, Zhixiang; Ning, Mengmeng; Zou, Qingan; Cao, Hua; Ye, Yangliang; Leng, Ying; Shen, Jianhua; Chemical and Pharmaceutical Bulletin; vol. 64; 4; (2016); p. 326 – 339;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics