Category: 56984-32-8

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 56984-32-8, name is Ethyl 5-chloro-1-methyl-1H-pyrazole-4-carboxylate, A new synthetic method of this compound is introduced below., category: pyrazoles-derivatives

The 1 – methyl -5 – chlorine pyrazole -4 – formic acid ethyl ester (300 mg, 1 . 59 mmol), phenol (300 mg, 3 . 19 mmol) dissolved in DMF, is added cesium carbonate (1.52, 4 . 66 mmol), microwave reactor 130 C reaction 30 minutes, the reaction is finished, to be reaction liquid cooling to room temperature, poured into water, extracted with ethyl acetate, the organic layer using saturated salt water washing, drying of the organic layer, dryness, passes through the rapid preparation column purification product 280 mg, yield is 72%.

The synthetic route of 56984-32-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Shen Jianhua; Leng Ying; Zou Qingan; Ning Mengmeng; (116 pag.)CN105164112; (2017); B;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Related Products of 56984-32-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 56984-32-8 name is Ethyl 5-chloro-1-methyl-1H-pyrazole-4-carboxylate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: In a microwave reaction vessel was combined 15(300 mg, 1.59 mmol), phenol (300 mg, 3.19 mmol) and Cs2CO3(1.52 g, 4.66 mmol) in DMF. The vessel was sealed and the resulting mixture was heated at 120C by microwave for30 min. Then the reaction mixture was cooled to r.t., quenched with water and extracted with EtOAc three times. The organic layer was collected, washed with brine, dried over MgSO4 and filtered. After the solvent was removed, the crude was purified by flash column chromatography to yield 16a

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Ethyl 5-chloro-1-methyl-1H-pyrazole-4-carboxylate, and friends who are interested can also refer to it.

Reference:
Article; Chen, Zhixiang; Ning, Mengmeng; Zou, Qingan; Cao, Hua; Ye, Yangliang; Leng, Ying; Shen, Jianhua; Chemical and Pharmaceutical Bulletin; vol. 64; 4; (2016); p. 326 – 339;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 56984-32-8 as follows. name: Ethyl 5-chloro-1-methyl-1H-pyrazole-4-carboxylate

Example 12; [Show Image] Compound 6 was reacted with various benzylbromides in the presence of cesium carbonate to give Compounds A-26, A-27 and A-28.

According to the analysis of related databases, 56984-32-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Shionogi & Co., Ltd.; EP1953145; (2008); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Reference of 56984-32-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 56984-32-8 name is Ethyl 5-chloro-1-methyl-1H-pyrazole-4-carboxylate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

C. 5-Chloro-1-methyl-1H-pyrazole-4-carboxylic acid 5-Chloro-1-methyl-1H-pyrazole-4-carboxylic acid, ethyl ester (13 grams, 0.07 mole) and potassium hydroxide (7.8 grams, 0.14 mole) were combined in 75 ml. of ethanol and refluxed for six hours. The solution was cooled, poured over water, acidified with concentrated hydrochloric acid, and the precipitated solid collected, dried, and recrystallized from water. The resulting 5-chloro-1-methyl-1H-pyrazole-4-carboxylic acid was obtained in the amount of 5.4 grams and melted at 195-197 C. Analysis calculated for C5 H5 ClN2 O2 Theory: C, 37.53; H, 3.15; N, 17.15; Found: C, 37.68; H, 3.06; N, 17.69.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Ethyl 5-chloro-1-methyl-1H-pyrazole-4-carboxylate, and friends who are interested can also refer to it.

Reference:
Patent; Eli Lilly and Company; US4620865; (1986); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 56984-32-8, name is Ethyl 5-chloro-1-methyl-1H-pyrazole-4-carboxylate, A new synthetic method of this compound is introduced below., SDS of cas: 56984-32-8

Example 11; [Show Image] Compound 6 was reacted with various benzylalcohols to give Compounds A-21, A-22, A-23 and A-24 via Mitsunobu reaction.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Shionogi & Co., Ltd.; EP1953145; (2008); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Reference of 56984-32-8, A common heterocyclic compound, 56984-32-8, name is Ethyl 5-chloro-1-methyl-1H-pyrazole-4-carboxylate, molecular formula is C7H9ClN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 11; [Show Image] Compound 6 was reacted with various benzylalcohols to give Compounds A-21, A-22, A-23 and A-24 via Mitsunobu reaction.

The synthetic route of 56984-32-8 has been constantly updated, and we look forward to future research findings.