Some common heterocyclic compound, 660845-30-7, name is 5-Chloro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carbaldehyde, molecular formula is C6H5ClF2N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 5-Chloro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carbaldehyde
30 g of 1-methyl-3-difluoromethyl-5-chloro-4-carbaldehyde-1H-pyrazole obtained in step (2)Was added to a 250ml single-neck flask,100 ml of N, N-dimethylformamide,Adding 2 times the molar amount of anhydrous potassium fluoride,The reaction was complete by heating and refluxing for 5 hours.The solvent was distilled off under reduced pressure,The residue was added to 100 ml of water,Extracted with ethyl acetate,The ethyl acetate was dried over anhydrous magnesium sulfate,Ethyl acetate was distilled off to give 21 g of a brown solid.The brown solid is 1-methyl-3-(difluoromethyl)-5-fluoro-1H-pyrazole-4-carbaldehyde
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 660845-30-7, its application will become more common.
Reference:
Patent; Zhejiang Chemical Engineering Research Institute Co., Ltd.; Xu, Tianming; Hu, Weiqun; Kong, Xiaolin; Zhang, Ruirui; Zheng, Zhiwen; Zhu, Weigang; Chen, Jie; Huang, Hongying; Yuan, Jing; (49 pag.)CN106336380; (2017); A;,
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