Adding a certain compound to certain chemical reactions, such as: 100114-57-6, name is 3-Cyclopropyl-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 100114-57-6, SDS of cas: 100114-57-6
The procedure is similar to Step 1[N55y6629j in Example- 839. 0.5 g of 6-chloro-N-(4, 4-difluorocyclohexyl)-4-methylpyridin-2-amine gave 6-(3 -cyclopropyl- 1 H-pyrazol- 1 -yl)-N-(4, 4-difluorocyclohexyl)-4-methylpyridin-2-amine as a white solid (0.11 g, 19%). MS (M+1)+=333.1; 1H-NMR (400 MHz, DMSO-d6): 8.36 (s, 1H), 6.77 (s, 1H), 6.62 (d, J= 7.20 Hz, 1H), 6.18 (d, J= 5.20 Hz, 2H), 3.96 (s, 1H), 2.20 (s, 3H), 2.10-1.90 (m, 7H), 1.60-1.45 (m, 2H), 0.92-0.85 (m, 2H), 0.77-0.71 (m, 2H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Cyclopropyl-1H-pyrazole, and friends who are interested can also refer to it.
Reference:
Patent; CADENT THERAPEUTICS, INC.; ERIKSEN, Birgitte, Langer; GUSTAFSSON, Magnus; HOUGAARD, Charlotte; JACOBSEN, Thomas, Amos; JEFSON, Martin, R.; KLEIN, Jessica; LARSEN, Janus, Schreiber; LOWE, John, A., III; MCCALL, John, M.; STROØBAeK, Dorte; VON SCHOUBYE, Nadia, Lyb°l; KEANEY, Gregg, F.; (752 pag.)WO2017/210545; (2017); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics