Synthetic Route of 1001020-14-9,Some common heterocyclic compound, 1001020-14-9, name is 3-(Trifluoromethyl)-1H-pyrazole-4-carbaldehyde, molecular formula is C5H3F3N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
e) 2-(2-(4-Formyl-3-(trifluoromethyl)-1 H-pyrazol-1 -yl)acetamido)-N-(2-hydroxyethyl)- 4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide2-(2-Bromoacetamido)-N-(2-hydroxyethyl)-4,5,6,7-tetrahydrobenzo[b]thiophene-3- carboxamide (2.91 g, 8.06 mmol) was dissolved in DMF (25 ml.) and potassium carbonate (2.23 g, 16.11 mmol), followed by 3-(trifluoromethyl)-1 H-pyrazole-4-carbaldehyde (1.39 g, 8.46 mmol), added. The mixture was stirred at 60 0C for 25 min after which time the reaction mixture was diluted with water (-800 ml_), then acidified with 5 N HCI until pH 1. During acidification a free flowing solid was obtained which was collected by filtration. NMR analysis indicated ~60-70 % purity of desired product. The solid was succesfully triturated with a mixture of DCM/ether to give a light beige solid which was collected by filtration. The mother liquor was concentrated and a second batch obtained using a similar process. The batches were combined to yield the title product (1.76 g, 3.95 mmol, 49 %). MS (ESI) : m/z 443.5 [M – H]
The synthetic route of 1001020-14-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; N.V. ORGANON; WO2008/3452; (2008); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics