Category: 1001020-14-9

Synthetic Route of 1001020-14-9,Some common heterocyclic compound, 1001020-14-9, name is 3-(Trifluoromethyl)-1H-pyrazole-4-carbaldehyde, molecular formula is C5H3F3N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

e) 2-(2-(4-Formyl-3-(trifluoromethyl)-1 H-pyrazol-1 -yl)acetamido)-N-(2-hydroxyethyl)- 4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide2-(2-Bromoacetamido)-N-(2-hydroxyethyl)-4,5,6,7-tetrahydrobenzo[b]thiophene-3- carboxamide (2.91 g, 8.06 mmol) was dissolved in DMF (25 ml.) and potassium carbonate (2.23 g, 16.11 mmol), followed by 3-(trifluoromethyl)-1 H-pyrazole-4-carbaldehyde (1.39 g, 8.46 mmol), added. The mixture was stirred at 60 0C for 25 min after which time the reaction mixture was diluted with water (-800 ml_), then acidified with 5 N HCI until pH 1. During acidification a free flowing solid was obtained which was collected by filtration. NMR analysis indicated ~60-70 % purity of desired product. The solid was succesfully triturated with a mixture of DCM/ether to give a light beige solid which was collected by filtration. The mother liquor was concentrated and a second batch obtained using a similar process. The batches were combined to yield the title product (1.76 g, 3.95 mmol, 49 %). MS (ESI) : m/z 443.5 [M – H]

The synthetic route of 1001020-14-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; N.V. ORGANON; WO2008/3452; (2008); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 1001020-14-9, name is 3-(Trifluoromethyl)-1H-pyrazole-4-carbaldehyde, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1001020-14-9, SDS of cas: 1001020-14-9

b) 2-(3-(4-Formyl-3-(trifluoromethyl)-1 H-pyrazol-1-yl)propanamido)-N-methyl-4, 5,6,7- tetrahydrobenzo[b]thiophene-3-carboxamide3-(Trifluoromethyl)-1 H-pyrazole-4-carbaldehyde (437 mg, 2.66 mmol) and 2-(3- chloropropanamido)-N-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide (801 mg, 2.66 mmol) were dissolved in DMF (15 ml_). Potassium carbonate (368 mg, 2.66 mmol) was added followed by potassium iodide (10 mg, 0.06 mmol). The reaction mixture was left to stand for 7 days. Water was added and the reaction mixture extracted into EtOAc (x 3). The EtOAc layers were combined and washed with water (x 5), brine, dried over MgSO4, filtered and the solvent removed in vacuo to give desired product as a yellow solid (970 mg, 2.26 mmol, 85 %). MS (ESI) : m/z 429.3 [M + H]+ .

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-(Trifluoromethyl)-1H-pyrazole-4-carbaldehyde, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 1001020-14-9, The chemical industry reduces the impact on the environment during synthesis 1001020-14-9, name is 3-(Trifluoromethyl)-1H-pyrazole-4-carbaldehyde, I believe this compound will play a more active role in future production and life.

To a stirred suspension of 3-(trifluoromethyl)-1H-pyrazole-4-carbaldehyde (100 mg, 0.609 mmol) and potassium tert-butoxide (137 mg, 1.22 mmol) in THF (3 mL) was added 2-(chloromethyl)-6-methyl-5-phenylthieno[2,3-d]pyrimidin-4(3H)-one (177 mg, 0.609 mmol) and the resultant solution was stirred at RT for 2 days. The reaction mixture was quenched with water and concentrated in vacuo to give the crude product as a beige solid (97 mg, 0.232 mmol, 38%). The material was used without further purification.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-(Trifluoromethyl)-1H-pyrazole-4-carbaldehyde, other downstream synthetic routes, hurry up and to see.

These common heterocyclic compound, 1001020-14-9, name is 3-(Trifluoromethyl)-1H-pyrazole-4-carbaldehyde, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 1001020-14-9

Example 862-(3-(4-((Methylamino)methyl)-3-(trifluoromethyl)-1 H-pyrazol-1-yl)propanamido)-4,5,6,7- tetrahydrobenzofblthiophene-3-carboxamidea) 2-(3-(4-Formyl-3-(trifluoromethyl)-1 H-pyrazol-1 -yl)propanamido)-4,5,6,7- tetrahydrobenzo[b]thiophene-3-carboxamide3-(Trifluoromethyl)-1H-pyrazole-4-carbaldehyde (260 mg, 1.585 mmol) and 2-(3- chloropropanamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide (454 mg, 1.585 mmol) were dissolved in THF (20 mL). Potassium tert-butoxide (356 mg, 3.17 mmol) was added followed by potassium iodide (10 mg, 0.06 mmol). The reaction mixture was stirred at RT overnight. Water was added and the reaction mixture extracted with EtOAc (x 3).The EtOAc layers were combined and washed with brine, dried over MgSO4, filtered and the solvent removed in vacuo to give a yellow gum (673 mg). Purification by flash column chromatography-silica gel gave the desired product as a white solid (180 mg, 0.43 mmol,27 %).MS (ESI) : m/z 415.1 [M + H]+ .

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1001020-14-9.

These common heterocyclic compound, 1001020-14-9, name is 3-(Trifluoromethyl)-1H-pyrazole-4-carbaldehyde, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 1001020-14-9

Example 862-(3-(4-((Methylamino)methyl)-3-(trifluoromethyl)-1 H-pyrazol-1-yl)propanamido)-4,5,6,7- tetrahydrobenzofblthiophene-3-carboxamidea) 2-(3-(4-Formyl-3-(trifluoromethyl)-1 H-pyrazol-1 -yl)propanamido)-4,5,6,7- tetrahydrobenzo[b]thiophene-3-carboxamide3-(Trifluoromethyl)-1H-pyrazole-4-carbaldehyde (260 mg, 1.585 mmol) and 2-(3- chloropropanamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide (454 mg, 1.585 mmol) were dissolved in THF (20 mL). Potassium tert-butoxide (356 mg, 3.17 mmol) was added followed by potassium iodide (10 mg, 0.06 mmol). The reaction mixture was stirred at RT overnight. Water was added and the reaction mixture extracted with EtOAc (x 3).The EtOAc layers were combined and washed with brine, dried over MgSO4, filtered and the solvent removed in vacuo to give a yellow gum (673 mg). Purification by flash column chromatography-silica gel gave the desired product as a white solid (180 mg, 0.43 mmol,27 %).MS (ESI) : m/z 415.1 [M + H]+ .

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1001020-14-9.