Synthetic Route of 181585-93-3, The chemical industry reduces the impact on the environment during synthesis 181585-93-3, name is Methyl 5-nitro-1H-pyrazole-3-carboxylate, I believe this compound will play a more active role in future production and life.
[00125] delta-Nitro-S-pyrazole-carboxylic acid methyl ester (22.35 g, 130.61 mmol) is dissolved in 160 ml_ THF und 160 ml_ glacial acetic acid. Then, Pd-C (10%, 4.36 g) is added and the reaction is stirred for 6 days under hydrogen atmosphere at RT. Then, the mixture is filtered over celite and the solvent is removed under vacuum. The crude material is dissolved in methylene chloride (800 ml_) and sodium hydrogen carbonate (200 g) is added, filtered and the solvent is again removed under vacuum. This procedure is repeated until the acetic acid smell is lost. delta-Amino-S-pyrazole-carboxylic acid methyl ester is isolated in high yields (16.91 g, 91.7 %)
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 5-nitro-1H-pyrazole-3-carboxylate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; MERZ PHARMA GMBH & CO. KGAA; HENRICH, Markus; WEIL, Tanja; HECHENBERGER, Mirko; MUeLLER, Sibylle; KAUSS, Valerjans; ZEMRIBO, Ronalds; ERDMANE, Elina; SMITS, Gints; WO2011/15343; (2011); A1;,
Pyrazole – Wikipedia,
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