Reference of 14531-55-6,Some common heterocyclic compound, 14531-55-6, name is 3,5-Dimethyl-4-nitro-1H-pyrazole, molecular formula is C5H7N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A mixture of 1.47g (15mmol) of 3,5-dimethylpyrazole, 1.02g (15mmol) of potassium hydroxide, and 10ml of DMSO was stirred at 80C for 1h. A solution of 1.98g (7.5mmol) of 1,4-bis(dibromomethyl)benzene in 10ml of DMSO was added dropwise, the mixture was stirred for 8h at 80C, diluted with 200ml of water, and the precipitate was filtered off ,washed with the mixture of ethanol and water, dried under reduced pressure.
The synthetic route of 14531-55-6 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Wang, Ji-Xiao; Zhu, Zi-Ran; Bai, Feng-Ying; Wang, Xin-Yu; Zhang, Xiao-Xi; Xing, Yong-Heng; Polyhedron; vol. 99; (2015); p. 59 – 70;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics