Adding a certain compound to certain chemical reactions, such as: 174891-10-2, name is 5-Amino-1H-pyrazole-3-acetic acid, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 174891-10-2, SDS of cas: 174891-10-2
mixture of 4-chloro-5-(2-chloroethoxy)-7-(2-methoxyethoxy)quinazoline (2.01g, 6.34mmol), (3-amino-lH-pyrazol-5-yl)acetic acid (0.89g, 6.31mmol) and hydrogen chloride (1.6ml of a 4M solution in 1,4-dioxane, 6.4mmol) in dimethylacetamide (20ml) were stirred at room temperature for 4 hours. The resulting thick suspension was added to water (100ml) then 40% aqueous sodium hydroxide solution added to pEta 12. 2N Hydrochloric acid was then added to re-adjust the pH to 4.8. The resulting pale orange solid was filtered, washed with water and dried over phosphorus pentoxide under high vacuum to give (3-{[5-(2- chloroethoxy)-7-(2-methoxyethoxy)quinazolin-4-yl]amino}-lH-pyrazol-5-yl)acetic acid (2.45g, 92% yield). MS (+ESI): 422 (M+H+).
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Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2006/67391; (2006); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics