Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 181585-93-3, name is Methyl 5-nitro-1H-pyrazole-3-carboxylate, A new synthetic method of this compound is introduced below., Recommanded Product: Methyl 5-nitro-1H-pyrazole-3-carboxylate
To a solution ofmethyl3-nitro-1H-pyrazole-5-carboxylate (342 mg, 2.0 mmol) macetone (40 mL) was added 1,2-dibromoethane (412 mg, 2.2 mmol), followed by K2C03 (828mg, 6. 0 mmol). The resulting mixture was stirred to reflux for 2 hrs. Then K2C03 was filteredoff The filtrate was concentrated in vacuo to give a residue, which was purified by silica gelcolumn (DC.lV1/MeOH = 50/1) to afford methyll-(2-bromoethyl)-3-nitro-lH-pyrazole-5-carboxylate (430 mg, yield: 77%) as yellow solid.[001034] 1H NMR (400 rviHz, CDCb): J = 7.42 (s, 1H), 5.08 (t, J = 6.4 Hz, 2H), 3.97 (s, 3H),3.78 (t, J = 6.4 Hz, 2H).
The synthetic route of 181585-93-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; JECURE THERAPEUTICS, INC.; STAFFORD, Jeffrey A.; VEAL, James M.; TRZOSS, Lynnie Lin; MCBRIDE, Christopher; (411 pag.)WO2018/136890; (2018); A1;,
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