Reference of 1029413-53-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1029413-53-3, name is tert-Butyl 3-(4-amino-1H-pyrazol-1-yl)pyrrolidine-1-carboxylate, This compound has unique chemical properties. The synthetic route is as follows.
Exam pie 20: Synthesis of I -(2-(2-(5-chioro-2-( I -(pyrroi id i n-3-yi)-I H-pyrazoi-4-yiamino) pyrimidin-4-yi)ethyi)phenyi)cyciopropanecarboxamide (20)(a) tert-Butyl 3-(4-(4-(2-(1-carbamoylcyclopropyl)phenethyl) -5-chloropyrimidin-2- ylamino)- 1H-pyrazol- 1-yI)pyrrolidine- 1-carboxylate (A21)A stirred solution of 1-(2-(2-(2,5-dichloropyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide A 14 (0.150 g, 0.446 mmol), 4-amino-1-(1-Boc-pyrrolidin-3-yl)-1H-pyrazole (0.225 g, 0.892 mmol) in MeOH (10 mL) and water(1.0 mL) was heated at 70 C for 2 days. Additional 4-amino-1-(1-boc-pyrrolidin-3-yl)-1H-pyrazole (0.125 g, 0.446 mmol) was added and the mixture was heated for afurther 16 hours at reflux. After cooling the solvent was removed to afford a crude red oil which was purified by silica gel column chromatography (0-100% EtOAc in cyclohexane) to give the title compound A21 as a red oil (0.164 g, 67% yield). LCMSC: rt 5.51 mm; m/z 551.9 [M+H].
The chemical industry reduces the impact on the environment during synthesis tert-Butyl 3-(4-amino-1H-pyrazol-1-yl)pyrrolidine-1-carboxylate. I believe this compound will play a more active role in future production and life.
Reference:
Patent; CANCER THERAPEUTICS CRC PTY LIMITED; FOITZIK, Richard Charles; MORROW, Benjamin Joseph; HEMLEY, Catherine Fae; LUNNISS, Gillian Elizabeth; CAMERINO, Michelle Ang; GANAME, Danny; STUPPLE, Paul Anthony; LESSENE, Romina; KERSTEN, Wilhelmus Johannes Antonius; HARVEY, Andrew John; HOLMES, Ian Peter; WO2014/26243; (2014); A1;,
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