Application of 71229-85-1,Some common heterocyclic compound, 71229-85-1, name is 4-Bromo-1-ethyl-1H-pyrazole, molecular formula is C5H7BrN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
In a nitrogen atmosphere, a mixture of 1.62 g of 4-methoxy-3-methyl-phenylboronic acid, 1.57 g of 4-bromo-1-ethyl-1H-pyrazole (9X), 0.79 g of a 1,1?-bis(diphenylphosphino)ferrocene-palladium(II) dichloride-dichloromethane complex, 3.51 g of sodium carbonate, 100 ml of 1, 4-dioxane, and 30 ml of water was stirred with heating under reflux for 4 hours. The reaction mixture was extracted with ethyl acetate, and the organic layer was washed with water, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. The residue thus obtained was subjected to silica gel column chromatography to obtain 1.3 g of 9Y represented by the following formula.
The synthetic route of 71229-85-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; DOTA, Koichiro; (92 pag.)US2017/105415; (2017); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics