Adding a certain compound to certain chemical reactions, such as: 288-13-1, name is 1H-Pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 288-13-1, HPLC of Formula: C3H4N2
Example 56:; N-[6-(2-Hydroxy-2H-pyrazol-3-yl)-2,4-dioxo-7-trifluoromethyl-l,4-dihydro-2H-quinazolin-3-yl]-methanesulfonamide; Pyrazol-1-ol; OHHVi N O.A mixture of pyrazole (10 g, 147 mmol) and mCPBA (36.2 g, 147 mmol) in AcOEt (500 mL) was stirred at r.t. for 1O d. The solution was concentrated in vacuo to afford a yellow paste which was extracted with water (6 x 100 mL) and coned HCl (100 mL). The aqueous phase was washed with DCM (2 x 100 mL). The organic layers were combined, concentrated in vacuo and extracted with coned HCl (50 mL). The aqueous phases were combined and 115 g of trisodium phosphate dodecahydrate were added followed by NaOH until pH 10. The aqueous phase was concentrated in vacuo to a volume of 400 mL and was then extracted in continue with OCMfEt2O (2/3) for 40 h. The organic phase was concentrated in vacuo and the residue dissolved in CHCl3. The insoluble material was removed by filtration and washed with EPO
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1H-Pyrazole, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2006/108591; (2006); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics