These common heterocyclic compound, 288148-34-5, name is 1-Methyl-1H-pyrazole-4-sulfonyl chloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 288148-34-5
te/f-Butyl (2-[1-(4-chlorophenyl)cyclobutyl]-2-{3-[(methylamino)methyl]phenyl}ethyl)carb- amate (35 mg, 0.082 mmol) was dissolved in dichloromethane (0.8 mL). 4-Dimethylamino- pyridine (10 mg, 0.082 mmol) and 1-methyl-1 H-pyrazole-4-sulfonyl chloride (16 mg, 0.09 mmol) was added. The reaction mixture was stirred at room temperature over night. The reaction mixture was diluted with ethyl acetate (20 ml) and washed with aqueous hydrochloric acid (1 N, 5 ml, twice) and sodium bicarbonate. The organic layer was dried (magnesium sulfate) and concentrated in vacuo. The crude product was purified by preparative thin layer chromatography (silica, ethyl acetate, n-heptane). Yield: 36 mg(0.063 mmol, 77%)ESI-MS [M-C02-isobutene+H+] = 473 Calculated for C29H37CIN4O4S = 572
The synthetic route of 1-Methyl-1H-pyrazole-4-sulfonyl chloride has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ABBOTT GMBH & CO. KG; ABBOTT LABORATORIES; AMBERG, Wilhelm; OCHSE, Michael; LANGE, Udo; BEHL, Berthold; HORNBERGER, Wilfried; MEZLER, Mario; POHLKI, Frauke; TURNER, Sean; HUTCHINS, Charles; WO2012/20130; (2012); A1;,
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