Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 916766-83-1, name is 3-(4-(Chloromethyl)phenyl)-1-methyl-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 916766-83-1
To a mixture of 3- ( (3S, 4S) -4-hydroxytetrahydro-2H-pyran- 3-yl) -7-methyl-6- (4,4,5, 5-tetramethyl-l, 3, 2-dioxaborolan-2-yl ) – 2H-benzo [e] [1, 3] oxazin-4 (3H) -one (0.10 g), 3-(4- (chloromethyl) phenyl) -1-methyl-lH-pyrazole (0.06 g) ,tetrakis (triphenylphosphine) alladium (0) (15 mg) , and DME (3 mL) was added 2 M aqueous sodium carbonate solution (0.26 mL) at room temperature, and the mixture was stirred under an argon atmosphere at 80C overnight. The reaction mixture was diluted with ethyl acetate, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (ethylacetate/hexane) and crystallized from ethyl acetate to give the title compound (0.05 g) .XH NMR (300 MHz, DMSO-d6) delta 1.33-1.64 (1H, m) , 1.81-1.96 (1H, m) , 2.24 (3H, s) , 3.31-3.50 (2H, m) , 3.64-3.73 (1H, m) , 3.75- 3.84 (1H, m) , 3.86 (3H, s) , 3.87-4.01 (4H, m) , 5.06 (1H, d, J = 5.3 Hz), 5.18-5.39 (2H, m) , 6.62 (1H, d, J = 2.3 Hz), 6.89 (1H, s), 7.14 (2H, d, J = 8.3 Hz), 7.54 (1H, s) , 7.65-7.73 (3H, m) .
According to the analysis of related databases, 916766-83-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; SUGIMOTO, Takahiro; SUZUKI, Shinkichi; SAKAMOTO, Hiroki; YAMADA, Masami; NAKAMURA, Minoru; KAMATA, Makoto; SHIMOKAWA, Kenichiro; OGINO, Masaki; KIMURA, Eiji; MURAKAMI, Masataka; YONEMORI, Jinichi; KOJIMA, Takuto; (281 pag.)WO2016/208775; (2016); A1;,
Pyrazole – Wikipedia,
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