Synthetic Route of 916766-83-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 916766-83-1, name is 3-(4-(Chloromethyl)phenyl)-1-methyl-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
A mixture of methyl1H-pyrrolo[3,2-b]pyridine-3-carboxylate (2.2 g, 12.50mmol), 3-[4-(chloromethyl)phenyl]-1-methyl-1H-pyrazole(3.04 g, 12.5 mmol), and KOH (1.4 g, 25.0 mmol) in acetone (80 mL) was stirredat 50 C for 18 h. The reaction mixture was concentrated, diluted with 100 mLof H2O, and neutralized to pH 7 with 6.0 M aq. HCl. The aq. mixture was extracted with EtOAc (2 x100 mL), and the combined extracts were dried (Na2CO3),filtered, and concentrated to afford 4.3 g (99%) of intermediate 7a as a yellow solid. Intermediate 7a was used in the following step without additional purification.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-(4-(Chloromethyl)phenyl)-1-methyl-1H-pyrazole, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Davoren, Jennifer E.; O’Neil, Steven V.; Anderson, Dennis P.; Brodney, Michael A.; Chenard, Lois; Dlugolenski, Keith; Edgerton, Jeremy R.; Green, Michael; Garnsey, Michelle; Grimwood, Sarah; Harris, Anthony R.; Kauffman, Gregory W.; Lachapelle, Erik; Lazzaro, John T.; Lee, Che-Wah; Lotarski, Susan M.; Nason, Deane M.; Obach, R. Scott; Reinhart, Veronica; Salomon-Ferrer, Romelia; Steyn, Stefanus J.; Webb, Damien; Yan, Jiangli; Zhang, Lei; Bioorganic and Medicinal Chemistry Letters; vol. 26; 2; (2016); p. 650 – 655;,
Pyrazole – Wikipedia,
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