Adding a certain compound to certain chemical reactions, such as: 709-04-6, name is 1-Phenyl-1H-pyrazole-4-carbonitrile, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 709-04-6, category: pyrazoles-derivatives
To a solution of nitrile 1011(300 mg, 1.77 mmol) in TI-IF (3 mL) was added Ti(O4Pr)4 (0.6 mL, 194 mmoi) at room temperature. Grignard reagent (4.5 mL, 443 mmoi)was added to the reaction mixture dropwise under argon atmosphere at -78C and the reaction mixture was stirred at -78C for 0.5 h and then at ambient temperature for 1 h. To the above reaction mixture at room temperature BF3OEt2 (0.5 mL, 3.54 rnrnoi) was added and stirred for I it After completion of reaction, the reaction mixture was quenched with water (3.0 mL), 2M HCI (2.0 mL) up to pI-i:::3 and stirred for 15 miii and then basified with 6N NaOH up to pH:::iO.The reaction mixture was extracted with 10% CH2C12/MeOH (15 mE >< 3). The combined organic layers were dried over anhydrous Na2SO4 and concentrated under reduced pressure. The crude residue was further purified by Combifiash column chromatography (CH?Cl2/I4eOH. 0 to 10%) to afford 1012 (60 mg, 1 7%) as an oil. MS (MM) miz 19g. I [M-4-H] -F.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Phenyl-1H-pyrazole-4-carbonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; IOMET PHARMA LTD.; MERCK SHARP & DOHME CORP.; COWLEY, Phillip, M.; HAN, Yongxin; (67 pag.)WO2017/48612; (2017); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics