Category: 709-04-6

Adding a certain compound to certain chemical reactions, such as: 709-04-6, name is 1-Phenyl-1H-pyrazole-4-carbonitrile, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 709-04-6, category: pyrazoles-derivatives

To a solution of nitrile 1011(300 mg, 1.77 mmol) in TI-IF (3 mL) was added Ti(O4Pr)4 (0.6 mL, 194 mmoi) at room temperature. Grignard reagent (4.5 mL, 443 mmoi)was added to the reaction mixture dropwise under argon atmosphere at -78C and the reaction mixture was stirred at -78C for 0.5 h and then at ambient temperature for 1 h. To the above reaction mixture at room temperature BF3OEt2 (0.5 mL, 3.54 rnrnoi) was added and stirred for I it After completion of reaction, the reaction mixture was quenched with water (3.0 mL), 2M HCI (2.0 mL) up to pI-i:::3 and stirred for 15 miii and then basified with 6N NaOH up to pH:::iO.The reaction mixture was extracted with 10% CH2C12/MeOH (15 mE >< 3). The combined organic layers were dried over anhydrous Na2SO4 and concentrated under reduced pressure. The crude residue was further purified by Combifiash column chromatography (CH?Cl2/I4eOH. 0 to 10%) to afford 1012 (60 mg, 1 7%) as an oil. MS (MM) miz 19g. I [M-4-H] -F. In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Phenyl-1H-pyrazole-4-carbonitrile, other downstream synthetic routes, hurry up and to see. Reference:
Patent; IOMET PHARMA LTD.; MERCK SHARP & DOHME CORP.; COWLEY, Phillip, M.; HAN, Yongxin; (67 pag.)WO2017/48612; (2017); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Synthetic Route of 709-04-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 709-04-6, name is 1-Phenyl-1H-pyrazole-4-carbonitrile belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

To a solution of nitrile 1011 (6.0 g, 35.5 mrnol) in THF (70 mL) at 0C was addedTi(O-i-Pr)4 (11.09 rnL, 39.05 rnmoi). To the above reaction mixture under argon atmosphere the1M solution of Grignard reag.ent in THF (78.1 mL, 78.1 mmoi) was added dropwise and thereaction mixture was stirred at —78C for 0.5 h. Then the reaction mixture was stirred at 0C for1.5 h. BF3OEt2 (10.0 rnL, 71.1 mrnol) was added to the above reaction mixture which wasstirred for 0.5 h. After completion of the reaction, the reaction mixture was treated with HCI (2N, 30 mL) and stirred for 15 mm and then basified with 6N NaOH. The mixture was extracted with ethyl acetate (3 x 100 mL) and the organic layers dried over anliydrous Na2SO,, and concentrated under reduced pressure. The crude residue was further purified by Combifiash column chromatography (ethyl acetate/hexane, 0 to 100%) to separate racemic 1021 A (1.0 g)(trans) and racernic 102 lB (0.8 g) (cis) oils.MS (MM) m/: 214.1[M±F1]/

The synthetic route of 1-Phenyl-1H-pyrazole-4-carbonitrile has been constantly updated, and we look forward to future research findings.

Reference:
Patent; IOMET PHARMA LTD.; MERCK SHARP & DOHME CORP.; COWLEY, Phillip, M.; HAN, Yongxin; (67 pag.)WO2017/48612; (2017); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics