Reference of 50877-41-3,Some common heterocyclic compound, 50877-41-3, name is 1-Benzyl-4-bromo-1H-pyrazole, molecular formula is C10H9BrN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step 2: Preparation of l-benzyl-4-(l-ethoxyvinyl)-lH-pyrazole [00168] Nitrogen was purged into a solution of l-benzyl-4-bromo-lH-pyrazole (0.55 g, 2.32 mmol) and tributyl(l-ethoxyvinyl)stannane (0.862 niL, 2.55 mmol) in toluene (15 niL) for 15 minutes. Then tetrakis(triphenylphosphine)palladium(0) (0.134 g, 0.116 mmol) was added and the reaction mixture was heated at 110 C for 12 h. The reaction mixture was filtered through celite and the filtrate was evaporated to afford the title compound l-benzyl-4-(l-ethoxyvinyl)- lH-pyrazole (0.52 g, crude) as a black liquid. The crude material was as such taken for next step without further purification.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Benzyl-4-bromo-1H-pyrazole, its application will become more common.
Reference:
Patent; MNEMOSYNE PHARMACEUTICALS, INC.; ANDERSON, David, R.; VOLKMANN, Robert, A.; MENNITI, Frank, S.; (181 pag.)WO2016/49165; (2016); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics