Reference of 96450-53-2, These common heterocyclic compound, 96450-53-2, name is 1-(2-Chloroethyl)-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A solution of Boc methylenedioxybenzenesulfonamide free phenol (0.010 g, 0.020 mmol) in acetone (1 ML) was combined with cesium carbonate (0.015 g, 0.047 mmol), 1-(2-chloroethyl)pyrazole (0.004 9, 0.031 mmol) and sodium iodide (~1 mg, 0.007 mmol).The solution was heated to 55 C. with stirring for 60 hours, and was cooled and dried in vacuo to give a yellow oil.Flash column chromatography (1:3 ethyl acetate/hexane) gave Boc methylenedioxybenzenesulfonamide ethylpyrazole tethered product (0.0015 g, 13%) as a colourless oil: Rf=0.20 (1:1 ethyl acetate/hexane); coupled LCMS showed the product as a single major peak with m/z 631 [M+H]+ at RT of 1.65 min.
The synthetic route of 96450-53-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Vertex Pharmaceuticals Incorporated.; US2004/122000; (2004); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics