Related Products of 54006-63-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 54006-63-2, name is 5-(4-Chlorophenyl)-1H-pyrazole-3-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows.
Acid 68 (0.898 mmol), HOBt (0.898 mmol) and N,O-dimethylhydroxylamine hydrochloride (0.898 mmol) were dissolved in CH2Cl2 (5 mL) and stirred for 10 min. EDC (0.898 mmol) in 5 mL of CH2Cl2 was added dropwise over 20 mins in which the colorless reaction mixture was stirred for 48 hrs. at room temperature under nitrogen. The reaction mixture was diluted with 10 mL of CH2Cl2, washed 2 times with water and twice with brine. The organic layer was dried with Na2SO4 and concentrated to give the amide 69 as a light yellow solid, which was used in the next step without further purification.
The chemical industry reduces the impact on the environment during synthesis 5-(4-Chlorophenyl)-1H-pyrazole-3-carboxylic acid. I believe this compound will play a more active role in future production and life.
Reference:
Patent; The Burnham Institute; US2010/16292; (2010); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics