Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 105994-77-2, name is 4-Bromo-1-methyl-5-phenyl-1H-pyrazole, A new synthetic method of this compound is introduced below., Application In Synthesis of 4-Bromo-1-methyl-5-phenyl-1H-pyrazole
General procedure: A mixture of 5.17 g of 4-chloro-1-ethyl-6-nitroquinolin-2(1H)-one, 4.26 g of cyclopropylboric acid monohydrate, 10.9 g of sodium carbonate, 0.44 g of bis(di-tert-butyl(4-dimethylaminophenyl)phosphine)dichloropalladium(II), 50 mL of ethylene glycol dimethyl ether, and 5.0 mL of water was heated to reflux under a nitrogen atmosphere for 3 hours. Thereafter, the reaction mixture was cooled to room temperature, and ethyl acetate and water were then added thereto. An organic layer was separated, was then successively washed with water and a saturated sodium chloride aqueous solution, and was then dried over anhydrous magnesium sulfate. The solvent was distilled away under reduced pressure. Diisopropyl ether, ethyl acetate and hexane were added to the obtained residue, and a solid was collected by filtration and was then washed with diisopropyl ether to obtain 4.81 g of 4-cyclopropyl-1-ethyl-6-nitroquinolin-2(1H)-one in the form of a slightly brown solid. 1H-NMR (CDCl3): 0.79-0.87 (2H, m), 1.15-1.24 (2H, m), 1.37 (3H, t, J=7.3 Hz), 2.11-2.23 (1H, m), 4.37 (2H, q, J=7. Hz), 6.54 (1H, s), 7.47 (1H, d, J=9.2 Hz), 8.42 (1H, dd, J=9.2, 2.6 Hz), 9.00 (1H, d, J=2.6 Hz).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; FUJIFILM Corporation; FUJIFILM Toyama Chemical Co., Ltd.; NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY; MAKITA, Keiko; SAEKI, Kazunori; TANAKA, Tadashi; FUJINO, Masataka; NATSUME, Tohru; FURUYA, Kentaro; (120 pag.)US2019/314360; (2019); A1;,
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