These common heterocyclic compound, 611239-23-7, name is tert-Butyl 1H-pyrazole-4-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C8H12N2O2
Synthetic Method B; Alternative procedure 2; Example 45: 1-(ff (2S)-4-(3. 4-Dichlorobenzvl) morpholin-2- vlmethvllcarbamovl) methvl)-1 H-pvrazole-4-carboxylic acid tert-butvl ester Potassium tert-butoxide (0.045g) was added to a solution 1 H-pyrazole-4- carboxylic acid ter-butyl ester (0.055g) in N, N-dimethylformamide (1ml). The mixture was stirred at 20C for 0.75h before a solution of Description 9 (0.099g) in N, N-dimethylformamide (0. 5ml) was added to it. The mixture was stirred at 20C for 2h then left to stand overnight. The mixture was diluted with ethyl acetate (35ml), washed with 1 M aqueous sodium bicarbonate solution (30mi) and water (30ml), dried over sodium sulphate and concentrated in vacuo to give a gum. The gum was purified on a 20g SPE cartridge, eluting initially with ethyl acetate and then with a (100: 1) mixture of ethyl acetate/methanol. The product containg fractions were evaporated in vacuo to give the title compound (0.032g) as a pale brown gum. LCMS Rt 2.62 min, m/z483 [MX]
The synthetic route of tert-Butyl 1H-pyrazole-4-carboxylate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GLAXO GROUP LIMITED; WO2003/82862; (2003); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics