Category: 611239-23-7

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 611239-23-7, name is tert-Butyl 1H-pyrazole-4-carboxylate, A new synthetic method of this compound is introduced below., Application In Synthesis of tert-Butyl 1H-pyrazole-4-carboxylate

To a solution of N-benzhydryl-6-chloro-4-methoxynicotinamide (200 mg, 0.6 mmol) in dioxane (16 mL) were added tert-butyl 1H-pyrazole-4- carboxylate (100 mg, 0.6 mmol), CuT (56 mg, 0.3 mmol), Cs2CO3 (550 mg, 1.7 mmol) and N,N-dimethylglycine (64 mg, 0.6 mmol). The mixture was stirred at 120C overnight. When TLC showed the reaction completed, the mixture was filtered. The filtrate was diluted with water (20 mL) and extractedwith EtOAc (40 mL). The organic layer was washed with brine (20 mL), dried over sodium sulfate and concentrated under vacuum. The residue was purified by prep. TLC (EtOAc /PE=3:1) to afford tert-butyl 1 -(5 -(benzhydrylcarbamoyl)-4- hydroxypyridin-2-yl)- 1 H-pyrazole-4- carboxylate. ?H NIVIR (CDC13,400 IVIHz) 12.87 (s, 1H), 8.88 (s, 1H), 8.50 (s, 1H), 8.02 (s, 1H), 7.55-7.50 (m, 1H), 7.42-7.27 (m, 11H), 6.41 (d, J= 7.3 Hz, 1H), 1.57 (s, 9H). LC/IVIS (m/z):471 (M+H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; MERCK SHARP & DOHME CORP.; UJJAINWALLA, Fez; TAN, John Qiang; DANG, Qun; SINZ, Christopher J.; WANG, Ming; CHEN, Yili; CAI, Jiaqiang; DU, Xiaoxing; (41 pag.)WO2016/54806; (2016); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

These common heterocyclic compound, 611239-23-7, name is tert-Butyl 1H-pyrazole-4-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C8H12N2O2

Synthetic Method B; Alternative procedure 2; Example 45: 1-(ff (2S)-4-(3. 4-Dichlorobenzvl) morpholin-2- vlmethvllcarbamovl) methvl)-1 H-pvrazole-4-carboxylic acid tert-butvl ester Potassium tert-butoxide (0.045g) was added to a solution 1 H-pyrazole-4- carboxylic acid ter-butyl ester (0.055g) in N, N-dimethylformamide (1ml). The mixture was stirred at 20C for 0.75h before a solution of Description 9 (0.099g) in N, N-dimethylformamide (0. 5ml) was added to it. The mixture was stirred at 20C for 2h then left to stand overnight. The mixture was diluted with ethyl acetate (35ml), washed with 1 M aqueous sodium bicarbonate solution (30mi) and water (30ml), dried over sodium sulphate and concentrated in vacuo to give a gum. The gum was purified on a 20g SPE cartridge, eluting initially with ethyl acetate and then with a (100: 1) mixture of ethyl acetate/methanol. The product containg fractions were evaporated in vacuo to give the title compound (0.032g) as a pale brown gum. LCMS Rt 2.62 min, m/z483 [MX]

The synthetic route of tert-Butyl 1H-pyrazole-4-carboxylate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GLAXO GROUP LIMITED; WO2003/82862; (2003); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics