Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 149978-43-8, name is 2-Methyl-5-trifluoromethyl-2H-pyrazol-3-ylamine, A new synthetic method of this compound is introduced below., Safety of 2-Methyl-5-trifluoromethyl-2H-pyrazol-3-ylamine
EXAMPLES EXAMPLE 1 5-(2-chloro-6-fluorophenyl)-N-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-1H-pyrazole-3-carboxamide [0112] Compound of Preparation 3 (100 mg, 0.42 mmol) and 1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-amine (76 mg, 0.46 mmol) were dissolved in 1.5 mL DMF. N-(3-Dimethylaminopropyl)-N’-ethylcarbodiimide hydrochloride 98% (62 mg, 0.46 mmol) and 1-Hydroxybenzotriazole hydrate (88 mg, 0.46 mmol) were added and the mixture was stirred at room temperature for 7 days. Dichloromethane was added and the organic phase was washed with water two times, saturated aqueous NaHCO3 solution and brine, dried over MgSO4 and evaporated under reduced pressure and the residue was purified using the Isolera purification (diethyl ether – hexane gradient, 0:100 rising to 100:0) to give 54 mg (0.13 mmol, 33%) of the title compound as a white solid. LRMS (m/z): 388 (M+1)+. 1 H NMR (300 MHz, CHLOROFORM-d) d ppm 3.90 (3 H, s), 6.69 (1 H, s), 7.11 – 7.23 (1 H, m), 7.33 – 7.45 (2 H, m), 8.69 (1 H, br. s)
The synthetic route of 149978-43-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Almirall, S.A.; GONZALEZ RODRIGUEZ, JACOB; VIDAL JUAN, BERNAT; GUAL ROIG, SILVIA; EP2848615; (2015); A1;,
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