Category: 149978-43-8

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 149978-43-8, name is 2-Methyl-5-trifluoromethyl-2H-pyrazol-3-ylamine, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 149978-43-8

Hydrochloric acid in 1,4-dioxane (10.5 mL, 42.0 mmol, 4 mol/L) followed by 1,1′- thiocarbonyldiimidazole (4.38 g, 23.3 mmol) were added to a stirred solution of l-methyl-3- (trifluoromethyl)-lH-pyrazol-5-amine [149978-43-8] (3.49 g, 21.1 mmol) in DCM (63 mL) under nitrogen. The reaction mixture was stirred at rt for 4.5 h before being left without stirring for a further 15.5 h. The reaction mixture was filtered and the pale yellow solid was washed with DCM (2 x 40 mL). The filtrate and washings were concentrated in vacuo to give an orange liquid which was purified by flash column chromatography on silica (gradient elution with 0% to 15% EtOAc in isohexane) to afford the title compound (3.0430 g, 14.688 mmol, 70%) as a colourless liquid. To confirm the presence of the title compound, a few drops of isobutylamine were added to the LCMS sample of the product before analysis to give the thiourea, LCMS [M+H]+ 281.0, RT 1.336 minutes, purity 100% (Method 15).

According to the analysis of related databases, 149978-43-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; UCB BIOPHARMA SRL; CHOVATIA, Prafulkumar Tulshibhai; CONNELLY, Rickki Lee; FRANKLIN, Richard Jeremy; HASLETT, Gregory William; HENRY, Alistair James; MADDEN, James; NEUSS, Judi Charlotte; NORMAN, Timothy John; PHILPS, Oliver; PITT, William Ross; RAMPALAKOS, Konstantinos; SELBY, Matthew Duncan; SELVARATNAM, Suganthan; TRANI, Giancarlo; ZHU, Zhaoning; (768 pag.)WO2019/243550; (2019); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 149978-43-8, name is 2-Methyl-5-trifluoromethyl-2H-pyrazol-3-ylamine, A new synthetic method of this compound is introduced below., Safety of 2-Methyl-5-trifluoromethyl-2H-pyrazol-3-ylamine

EXAMPLES EXAMPLE 1 5-(2-chloro-6-fluorophenyl)-N-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-1H-pyrazole-3-carboxamide [0112] Compound of Preparation 3 (100 mg, 0.42 mmol) and 1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-amine (76 mg, 0.46 mmol) were dissolved in 1.5 mL DMF. N-(3-Dimethylaminopropyl)-N’-ethylcarbodiimide hydrochloride 98% (62 mg, 0.46 mmol) and 1-Hydroxybenzotriazole hydrate (88 mg, 0.46 mmol) were added and the mixture was stirred at room temperature for 7 days. Dichloromethane was added and the organic phase was washed with water two times, saturated aqueous NaHCO3 solution and brine, dried over MgSO4 and evaporated under reduced pressure and the residue was purified using the Isolera purification (diethyl ether – hexane gradient, 0:100 rising to 100:0) to give 54 mg (0.13 mmol, 33%) of the title compound as a white solid. LRMS (m/z): 388 (M+1)+. 1 H NMR (300 MHz, CHLOROFORM-d) d ppm 3.90 (3 H, s), 6.69 (1 H, s), 7.11 – 7.23 (1 H, m), 7.33 – 7.45 (2 H, m), 8.69 (1 H, br. s)

The synthetic route of 149978-43-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Almirall, S.A.; GONZALEZ RODRIGUEZ, JACOB; VIDAL JUAN, BERNAT; GUAL ROIG, SILVIA; EP2848615; (2015); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics