Related Products of 75092-30-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 75092-30-7, name is 4-Iodo-1-methyl-1H-pyrazole-5-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows.
A suspension of Preparation 16 (50 mg, 0.0897 mmol), 4-iodo-2-methyl-2H-pyrazole-3-carboxylic acid (MFCD00461121) (23 mg, 0.0897 mmol), CS2CO3 (58 mg, 0.179 mmol) and PdCl2(dppf)2.CH2Cl2 (4 mg, 0.00448 mmoL) in 1,4-dioxane (0.8 mL) and H2O (0.2 mL) was stirred at 80 C. for 16 h. LCMS showed the reaction was complete. The reaction was dried over Na2SO4 and filtered. The filtrate was concentrated to dryness and purified by prep-HPLC (petroleum ether:EtOAc, 1:1) to give the N-BOC intermediate (10 mg, 20%) as a white solid. The reaction was repeated to obtain additional material.
The chemical industry reduces the impact on the environment during synthesis 4-Iodo-1-methyl-1H-pyrazole-5-carboxylic acid. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Pfizer Inc.; Darout, Etzer; Dullea, Robert; Hawkins, Julie Jia Li; Londregan, Allyn T.; Loria, Paula M.; Maguire, Bruce; McClure, Kim F.; Petersen, Donna N.; Piotrowski, David W.; US2014/315928; (2014); A1;,
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