Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 17827-61-1, name is Methyl 1-Methylpyrazole-3-carboxylate, A new synthetic method of this compound is introduced below., HPLC of Formula: C6H8N2O2
To a solution of Ir(COD)2(OMe)2 (5.00 mg, 7.54 pmol, 0.02 equiv) and 4, 4, 5, 5- tetramethyl-l, 3, 2-dioxaborolane (68.5 mg, 535 pmol, 77.7 pL, 1.50 equiv) in -pentane (0.50 mL) was added 4-/er/-butyl-2-(4-/er/-butyl-2-pyridyl)pyridine (5.00 mg, 18.6 pmol, 0.05 equiv) and the mixture was stirred at 25 C for 20 minutes. To this mixture was added a solution of methyl l-methylpyrazole-3-carboxylate (50.0 mg, 357 pmol, 1.00 equiv) in -pentane (0.50 mL) and THF (0.50 mL) and the mixture was stirred at 25 C for 24 h. The mixture was partitioned between ethyl acetate (10.0 mL) and water (10.0 mL). The organic phase was dried over anhydrous sodium sulfate and concentrated to afford the crude product methyl l-methyl-5-(4, 4, 5, 5-tetramethyl-l, 3, 2-dioxaborolan-2-yl)pyrazole-3-carboxylate (50.0 mg, 113 pmol, 31.6% yield, 60.0% purity) as a black oil. 1H NMR (400MHz, CDCl3) d = 7.28 (s, 1H), 4.15 (s, 3H), 3.93 (s, 3H), 1.35 (s, 12H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.