Application of 1353100-91-0,Some common heterocyclic compound, 1353100-91-0, name is Ethyl 3-bromo-1H-pyrazole-4-carboxylate, molecular formula is C6H7BrN2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
[0506] to a solution of compound 32b (5.6 g, 25.57 mmol) in DMF(200 ml) was added mel (14.52 g, 102.28 mmol, 6.37 ml) andCs2CO3 (33.32 g, 102.28 mmol). The mixture was stirred at 25 C for 12 hrs. The mixture was diluted with H2O (1000 ml) and extracted with ethyl acetate (500 ml), then the organic layer was washed with brine (500 ml x 3), dried over Na2SO4 and concentrated. The residue (4 g) was purified by preparatory-hplc (basic condition). The residue was purified by column chromatography (SiO2, petroleum ether/ethyl acetate=10/l to 5: 1). Compound 32c (1g, yield: 16.8%) was obtained as a white solid. Compound 32d (2 g, yield: 33.6%) was obtained as a white solid.
The synthetic route of 1353100-91-0 has been constantly updated, and we look forward to future research findings.