Some common heterocyclic compound, 916211-79-5, name is 5-Chloro-1H-pyrazol-3-amine, molecular formula is C3H4ClN3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 5-Chloro-1H-pyrazol-3-amine
A solution of ie/ -butyl (4S)-4-methoxy-3-oxo-pentanoate (1.96 g, 9.7 mmol) in DMF-DMA (1.25 mL) was heated at 120 C for 1 hour, then cooled to 80 C, and a solution of 3-chloro-lH-pyrazol-5-amine (1.14 g, 0.97 mmol) in EtOH (12.5 mL) was added. The resulting mixture was stirred for 2 hours at 80 C, then concentrated under reduced pressure. The residue was purified by silica chromatography (hexane: EtOAc= 5: 1 to 1: 1) to give the title compound (1.60 g, 53%). 1H NMR (400 MHz, DMSO-J6): delta 8.66 (s, 1H), 7.05 (s, 1H), 5.26 (q, 1H), 3.22 (s, 3H), 1.62 (d, 3H), 1.56 (s, 9H). MS m/z 312.24 [M+H]+.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 916211-79-5, its application will become more common.