Category: 916211-79-5

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 916211-79-5, name is 5-Chloro-1H-pyrazol-3-amine, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C3H4ClN3

A solution of ie/ -butyl 4-methyl-3-oxopentanoate (2.52 g, 13.6 mmol) in DMF-DMA (1.8 mL) was heated at 120 C for 1 hour. The solution was cooled to 80 C and a solution of 3- chloro-lH-pyrazol-5-amine (1.6 g, 13.6 mmol) in EtOH (21 mL) was added. The resulting mixture was stirred for 2 hours at 80 C. The solvent was removed in vacuo then concentrated under reduced pressure. The residue was purified by silica chromatography (petroleum ethenEtOAc = 40: 1) to give the title compound (2.1 g, 52% yield). 1H NMR (400 MHz, DMSO-Mu): delta 8.76 (s, 1H), 6.97 (s, 1H), 4.30 (m, 1H), 1.57 (s, 9H), 1.52 (d, = 7.2 Hz, 6H). MS m/z 296.45 [M+H]+.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 916211-79-5.

Reference:
Patent; CORNELL UNIVERSITY; DANA-FARBER CANCER INSTITUTE, INC.; CHILDREN’S MEDICAL CENTER CORPORATION; MELNICK, Ari, M.; GABAS, Lorena, Fontan; US, Ilkay; CASALENA, Gabriella; GRAY, Nathanael, S.; SCOTT, David, A.; HATCHER, John; DU, Guangyan; WU, Hao; QIAO, Qi; (157 pag.)WO2018/85247; (2018); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Some common heterocyclic compound, 916211-79-5, name is 5-Chloro-1H-pyrazol-3-amine, molecular formula is C3H4ClN3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 5-Chloro-1H-pyrazol-3-amine

A solution of ie/ -butyl (4S)-4-methoxy-3-oxo-pentanoate (1.96 g, 9.7 mmol) in DMF-DMA (1.25 mL) was heated at 120 C for 1 hour, then cooled to 80 C, and a solution of 3-chloro-lH-pyrazol-5-amine (1.14 g, 0.97 mmol) in EtOH (12.5 mL) was added. The resulting mixture was stirred for 2 hours at 80 C, then concentrated under reduced pressure. The residue was purified by silica chromatography (hexane: EtOAc= 5: 1 to 1: 1) to give the title compound (1.60 g, 53%). 1H NMR (400 MHz, DMSO-J6): delta 8.66 (s, 1H), 7.05 (s, 1H), 5.26 (q, 1H), 3.22 (s, 3H), 1.62 (d, 3H), 1.56 (s, 9H). MS m/z 312.24 [M+H]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 916211-79-5, its application will become more common.