Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 131797-35-8, name is 5-Chloro-3-(trifluoromethyl)-1H-pyrazole, A new synthetic method of this compound is introduced below., Product Details of 131797-35-8
To a mixture of 7-(chloromethyl)-3-propanoyl-2-(trifluoromethyl)-5H-[l,3]thiazolo[3,2- a]pyrimidin-5-one (15 mg, 0.05mmol) in acetonitrile (3 mL, 57.1mmol) was added potassium carbonate (13 mg, 0.09 mmol) and 5-chloro-3-(trifluoromethyl)-lH-pyrazole (10 mg, 0.06 mmol). The resulting mixture was stirred for 2 h at 80 C. After filtration and concentration, the residue was purified by chromatography with ethyl acetate/petroleum ether (1/3) to afford 7-[[5-chloro-3-(trifluoromethyl)-lH- pyrazol-l-yl]methyl]-3-propanoyl-2-(trifluoromethyl)-5H-[l,3]thiazolo[3,2-a]pyrimidin-5-one (4.5 mg, 21%) as a light brown solid. LCMS (ESI): M+H+ = 459.0; lU NMR (400 MHz, CDC13) delta 6.60 (s, 1H), 5.83 (s, 1H), 5.31 (s, 2H), 2.97-2.83 (m, 2H), 1.29-1.25 (m, 3H).
The synthetic route of 131797-35-8 has been constantly updated, and we look forward to future research findings.