Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 368870-03-5, name is (4-(1H-Pyrazol-1-yl)phenyl)methanamine, A new synthetic method of this compound is introduced below., Formula: C10H11N3
A mixture of methyl 3-((tetrahydrofuran-2-yl)methoxy)-5-vinylisonicotinate (0.18 g) obtained in Reference Example 47, sodium periodate (0.71 g) and osmium oxide (immobilized catalyst I) (0.084 g) and acetonitrile (4 mL)-acetone (4 mL)-water (4 mL) was stirred at room temperature overnight. The insoluble material was filtered off, the filtrate was ethyl acetate and water, and the organic layer was separated, washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated. The residue was dissolved in diethyl ether (5 mL)-THF (5 mL), (4-(1H-pyrazol-1-yl)phenyl)methanamine (0.10 g) and anhydrous magnesium sulfate (0.15 g) were added, and the mixture was stirred under a nitrogen atmosphere at room temperature for 1 hr. The insoluble material was filtered off, and the filtrate was concentrated. To a solution of the residue in acetic acid (5 mL) was added sodium triacetoxyhydroborate (0.28 g), and the mixture was stirred at room temperature for 3 hr. The reaction mixture was diluted with water and ethyl acetate. The organic layer was separated, washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated. The residue was purified by NH silica gel chromatography (hexane-ethyl acetate) to give the title compound (0.095 g). MS: [M+H]+ 391.2 1H NMR (300 MHz, DMSO-d6) delta 1.73-1.90 (2H, m), 1.97-2.07 (2H, m), 3.62-3.75 (1H, m), 3.82 (1H, t, J = 7.1 Hz), 4.20-4.33 (3H, m), 4.44 (2H, s), 4.72 (2H, s), 6.46-6.59 (1H, m), 7.41 (2H, d, J = 8.5 Hz), 7.73 (1H, d, J = 1.7 Hz), 7.82 (2H, d, J = 8.5 Hz), 8.40-8.51 (3H, m).
The synthetic route of 368870-03-5 has been constantly updated, and we look forward to future research findings.