Reference of 52222-73-8, The chemical industry reduces the impact on the environment during synthesis 52222-73-8, name is 4-(Trifluoromethyl)-1H-pyrazole, I believe this compound will play a more active role in future production and life.
To a solution of 2-chloro-5-nitrobenzonitrile (1 .278 g, 7.0 mmol) and 4-(trifluoromethyl)- iH-pyrazole (1 .0 g, 7.35 mmol) in acetonitrile (10 mL) was added potassium carbonate (2.90 g, 21 mmol) at RT. The mixture was heated to 60 C and stirred at this temperature for 1 hour. The reaction mixture was diluted with EtOAc (50 mL), and the solids were removed by filtration. The filtrate was concentrated in vacuo and the residue was purified by Biotage Isolera chromatography (silica gel, eluting with heptanes-EtOAc, 1 :0 to 0: 1 ). The product containing fractions were combined and concentrated in vacuo to afford 1 .77 g (89% yield) of the title compound as a yellow solid.1H NMR (500 MHz, DMSO-d6) delta [ppm] 9.28 (s, 1 H), 8.94 (d, J = 2.6 Hz, 1 H), 8.68 (dd, J = 9.0, 2.6 Hz, 1 H), 8.47 (s, 1 H), 8.19 (d, J = 9.0 Hz, 1 H).LCMS (Analytical Method A): Rt = 1 .16 mins; MS (ESIpos) m/z = 283.0 (M+H)
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