Adding a certain compound to certain chemical reactions, such as: 35344-95-7, name is 1H-Pyrazole-4-carbaldehyde, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 35344-95-7, category: pyrazoles-derivatives
NaH (60% in oil, 79 mg, 2.0 mmol) was added to a solution of Intermediate 7(172 mg, 1.79 mmol) in DMF (18 mL) at 0C, and the reaction was allowed to stir at 0Cfor 15 minutes. A solution of 4-(bromomethyl)-1,1?-biphenyl (442 mg, 1.79 mmol) in 5mL of DMF was then added at 0C. The reaction stirred at 0 C for 1.5 hours, then allowed to warm to rt, and stirred for 5 minutes before quenching with water. The reaction was diluted with EtOAc, washed with 10% aq. LiC1 solution and brine, dried with Na2SO4, filtered and concentrated. The crude mixture was purified by silica gelchromatography to yield 39A (424 mg, 90.3%) as a white solid. MS(ESI) m/z 397.9 (M+H)h
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1H-Pyrazole-4-carbaldehyde, and friends who are interested can also refer to it.