Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1192-21-8, name is 1-Methyl-1H-pyrazol-5-amine, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 1192-21-8
2nd Generation XantPhos precatalyst (26.4 mg, 0.03 mmol) was added to (5)-2-(2,5- dichloropyrimidin-4-yl)-6-methyl-7-((6-methylpyridin-2-yl)methyl)-6,7- dihydroimidazo[l,2-a]pyrazin-8(5H)-one (Intermediate 46; 120 mg, 0.30 mmol), 1-methyl- lH-pyrazol-5-amine (72.2 mg, 0.74 mmol) and Cs2C03 (194 mg, 0.60 mmol) in 1,4- dioxane (8 mL) at 25 ¡ãC under nitrogen. The resulting mixture was stirred at 100 ¡ãC for 8 hours. The solvent was then removed under reduced pressure. The crude product was purified by flash silica chromatography, elution gradient 0 to 6percent MeOH in DCM. Pure fractions were evaporated to dryness to afford a yellow residue. This residue was further purified by preparative HPLC (XSelect CSH Prep CI 8 OBD column, 5mu silica, 19 mm diameter, 150 mm length), using decreasingly polar mixtures of water (containing 0.03percent NH3) and MeCN as eluents. Fractions containing the desired compound were evaporated to dryness to afford (5)-2-(5-chloro-2-((l-methyl-lH-pyrazol-5-yl)amino)pyrimidin-4-yl)-6- methyl-7-((6-methylpyridin-2-yl)methyl)-6,7-dihydroimidazo[l,2-a]pyrazin-8(5H)-one (Example 11; 50 mg, 36.2percent) as a white solid. H NMR (400 MHz, DMSO, 22 ¡ãC) delta 1.19 (3H, d), 2.47 (3H, s), 3.70 (3H, s), 4.08 (IH, d), 4.32 – 4.43 (2H, m), 4.53 (IH, dd), 5.15 (IH, d), 6.31 (IH, d), 7.21 (2H, dd), 7.34 (IH, d), 7.68 (IH, t), 8.21 (IH, s), 8.53 (IH, s), 9.72 (IH, s). m/z (ES+), [M+H]+ = 464
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1192-21-8.