Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 27258-33-9, name is 1-Methyl-1H-pyrazole-5-carbaldehyde, A new synthetic method of this compound is introduced below., Formula: C5H6N2O
To a solution of triethyl phosphonoacetate (26.9 g) in tetrahydrofuran (200 ml) was added sodium hydride (60% dispersion in mineral oil, 4.8 G) by portions under ice- cooling. The mixture was stirred at the same temperature for 1 hour. To the reaction mixture was added 1-METHYL-LH-PYRAZOLE- 5-carbaldehyde (33.0 g) in tetrahydrofuran (165 ml) at room temperature, and the mixture was stirred at the same temperature for 1.5 hours. To the resulting solution was added 10% aqueous potassium hydrogen sulfate solution. The mixture was extracted with ethyl acetate twice. The combined organic layers were washed with saturated sodium hydrogen carbonate solution and brine. The extract was dried over anhydrous magnesium sulfate, filtered and concentrated in vacuo. The residue was purified by silica gel column chromatography to give ethyl (2E)-3-(1-METHYL-LH-PYRAZOL-5-YL)-2-PROPENOATE (33.4 g) as an oil. IR (neat) 2981,2943, 1713,1703, 1180,781 CM~1. H-NMR (DMSO-d6) 8 1. 26 (3H, t, J = 7.1 Hz), 3.88 (3H, s), 4.20 (2H, q, JAZZ 7.1 Hz), 6.54 (1H, d, J = 15.8 Hz), 6.88 (1H, d, J = 1.8 Hz), 7.45 (1H, d, J = 1.8 Hz), 7.60 (1H, d, J = 15.8 Hz). MS (APCI) 181 (M+H+).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.