Reference of 151049-87-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 151049-87-5 as follows.
A 30m1 tube was charged with ethyl N-(diphenylmethylene)glycinate (2.5 g, 9.35 mmol), 3-bromo-1-methyl-lh-pyrazole (1.51 g, 9.35 mmol), potassium phosphatetribasic (6 g, 27.7 mmol) in toluene (15 mL) and the mixture was purged with N2 for 5 minutes. Bis(tri-tert-butylphosphine)palladium(0) (526 mg, 1.03 mmol) was added and the vial was capped and the mixture was stirred at 100C for 16 hours. The mixture was cooled and filtered over decalite. The filtrate was concentrated in vacuo. The residue was purified by column chromatography using a gradient from 0 till 100% EtOAc inheptane. The product fractions were concentrated in vacuo to yield ethyl2-(benzhydrylideneamino)-2-( 1 -methylpyrazol-3 -yl)acetate (1.95 g) as a pale yellow oil.
According to the analysis of related databases, 151049-87-5, the application of this compound in the production field has become more and more popular.