Synthetic Route of 67-51-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 67-51-6 as follows.
General procedure: NaH (60mmol) was added to the solution of 3,5-dimethylpyrazole or 3,5-diisopropylpyrazole (50mmol) in THF (40ml) at room temperature. The resulting mixture was stirred for 1h, and then CH3I (50mmol) was added. After the reaction mixture was continuously stirred overnight at room temperature, water (100ml) was added slowly. The solution was extracted with ethyl acetate (3¡Á50ml). The organic layers were combined, washed with saturated brine and dried over anhydrous MgSO4. The solvent was removed in vacuo to give the expected products. (0012) 1,3,5-Trimethylpyrazole, yield: 46%. 1H NMR: delta 2.18 (s, 3H), 2.19 (s, 3H) (CH3), 3.67 (s, 3H, NCH3), 5.76 (s, 1H, H4 of pyrazole) ppm. 13C NMR: delta 11.0, 13.4 (CH3), 35.6 (NCH3), 104.8 (C4 of pyrazole), 139.0, 147.0 (C3 and C5 of pyrazole) ppm.
According to the analysis of related databases, 67-51-6, the application of this compound in the production field has become more and more popular.