Reference of 368870-03-5,Some common heterocyclic compound, 368870-03-5, name is (4-(1H-Pyrazol-1-yl)phenyl)methanamine, molecular formula is C10H11N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
6 mmol of compound III was dissolved in 30 mL of N, N-dimethylformamide (DMF), followed by 30 mmol of 4-dimethylaminopyridine (DMAP). 7 mmol of intermediate IIb was added thereto at room temperature. After the addition, the temperature was raised to 100 C for 16 hours. The reaction was stopped, the reaction solution was poured into ice water, and extracted with ethyl acetate several times. After the organic phase was dried, the obtained crude product was concentrated and separated by column chromatography to obtain the target Ib.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route (4-(1H-Pyrazol-1-yl)phenyl)methanamine, its application will become more common.