Related Products of 1260243-04-6, A common heterocyclic compound, 1260243-04-6, name is Ethyl 5-amino-1H-pyrazole-4-carboxylate, molecular formula is C6H9N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a mixture of ethyl 5-amino- 1H-pyrazole-4-carboxylate (1.0 g, 6.493 mmol) in AcOH (15 mL) was added 1,1,1-trifluoropentane-2,4-dione (1.0 g, 6.493 mmol) at 110 ¡ãC. The mixture was stirred for 2 hours and concentrated in vacuo. The residue was dissolved in EA(100 mL). The organic solution was washed with 10percent NaHCO3 solution (50 mL), dried over anhydrous Na2SO4 and filtered. The filtrate was concentrated in vacuo to afford ethyl 7-methyl- 5 -(trifluoromethyl)pyrazolo [1,5-al pyrimidine-3 -carboxylate (1.8 g, 100percent) as a yellow solid.LC-MS m/z: 274.0 [M+Hf?. tR= 1.71 mm.
The synthetic route of 1260243-04-6 has been constantly updated, and we look forward to future research findings.